We are Hiring!

We are offering a full-time Postdoctoral position in our lab. This role combines planning and conducting experiments, preparing publications, and teaching in the medical program. The postdoc is expected to propose and develop a research project that fits to the general interests of the group. Requirements for the position are a Dr. or PhD in Natural Sciences. Ideal candidates would have a strong interest in comparative neuroanatomy with experience in immunohistochemistry and/or MRI analysis. Since teaching will be in German, candidates must have profound knowledge of German (B1 level or higher). For Further information click here. Application can be send directly to Nina Patzke.

It is offical, Patzke lab moved to an new Location. We are based now at the Health and Medical University in Potsdam Gemany. The boxes are still being unpacken and the lab set up is in progress. Stay tuned for more updates!

Aya Komemura (left) and Kaede Watanabe (right) finished their undergrad studies. Ayu and Kaede carried out a histological analysis of astrocytes in carnivores and cetratiridactyls. Well done! And all the best for the future.

We are busy packing up the lab. After 4.5 successful years at Hokkaido University the Patzke lab is moving to a new destination. Stay tuned for more updates!

Over the span of two weeks our laboratory hosted 2 HSI courses on brain morphology and evolution. Students and instructors from 5 different countries participated in these 2 courses. We would like to thank all participants who made these 2 HSI courses a big success. We are looking forward to host them next year again.

Undergraduate level: Fundamentals of Comparative Neuroanatomy and Behaviour: from birds to whales

Postgraduate level: Mammalian Brain Morphology: From specimen collection to mathematical modeling

Suzuka Iritani (left) and Minasa Kasai (right) finished their excellent undergrad studies. Suzuka demonstrated that the hippocampus of seals is smaller when compared to their land-living relatives, the Carnivores. Minasa did a histological analysis of the dolphin’s amygdala. Well done! Suzuka will continue with her Master studies in our lab.

Whales and dolphins lose heat to their aquatic environment 90 times faster than terrestrial animals in air. 

Even a slight drop in brain temperature makes many neurons inactive, greatly reducing mental activity. In a recent study we demonstrate that whales and dolphins possess a specialized brain heat-producing system to combat this environmental pressure of heat loss. They have the internal chemistry that allows the brain to function as its own heating element. 

Proteins called uncoupling proteins (UCPs) are involved in this internal heat production by preventing efficient ATP production for normal neuronal functions and instead convert this energy as heat. Results of the study showed that 90% of the neurons in whale and dolphin brains contain UCPs, much more than closely related species (such as the river hippopotamus that only has 35% of UCP containing neurons). 

30 to 70% of glia cells of whales and dolphins contain UCPs, which is 30% denser than other related species. Furthermore,  nerve terminals that contain the neurotransmitter noradrenaline are about 30% denser in whale and dolphin brains when compared to closely related species. Noradrenaline is involved in processes that control the concentration and activity of UCPs. 

These findings show that cetaceans have an increased ability for thermogenesis due to higher expression of UCPs. These heat-regulation mechanisms may have contributed to the evolution of large brain size in whales and dolphins.

Jinta Kasai has finsihed his Master thesis. All the best for your new job!